Biofabricated Leather

Biofabricated leather is created from small samples of living animal skin cells, multiplied in bioreactors and 'printed' into sheets, which can be tanned and used like normal leather, grown to larger sizes, or even bioengineered for new properties

Biotechnologists have been improving processes for growing living tissues in vitro (outside the body, in the lab) for many years. Several organisations are now developing ‘biofabricated’ (or ‘bioprinted’) products using these techniques, such as in vitro liver and skin culturing for medical procedures, slaughter free meat and, in this case, leather.

The claimed benefit over existing ‘fake’ leathers is that it is almost the same tissue and structure as real animal leather so has similar properties and performance. The claimed benefits over both fake leather which is usually made of petroleum products, and animal leather, are ethical considerations and sustainability. A study found that cultured meat could use 99% less land, 96% less water, 45% less energy and with 96% less greenhouse gas production than conventional animal farming, for example.

Startup Modern Meadow is pioneering with it’s first product ‘Zoa‘ (swatches pictured above and T-Shirt using it pictured below) a ‘bioleather’ that is “designed and grown from animal free collagen, which can be combined with other natural or manmade materials offering new aesthetic and performance properties.” Unlike animal grown leather, the material is “able to be any density,” “hold to any mold” and “take on any texture”, with genetic engineering potentially widening the range of properties even further. See founder Andras Forgacs’ TEDx talk.

zoa.is (Modern Meadow)

Other pioneers include VitroLabs (incubated at Future Tech Lab; “a disruptive movement of innovators bridging together fashion and science to create a sustainable future.”) which uses stem-cell technology and tissue engineering to create ethical leather from cow, ostrich and crocodile cells.

Vitro Labs Inc.

Note that the technology is in its infancy, so large ranges of refined products and production-scale supply chains are not yet established.

Uses

  • Fashion: the Zoa-leather detailed T-shirt pictured above, and exhibited at MOMA is the only finished product we have found, and not for sale as far as we know.

Potential Uses

  • Anywhere that conventional leather is used; clothing, accessories, furniture etc.
  • If properties and sizes are developed beyond those available in conventional leather then new use cases may arise; building facades / roofs? tents? aeroplane ‘skin’? bedding? lorry tarpaulins? curtains? room dividers? geo-textiles?…
  • Any other ideas or exploratory projects you are aware of please do comment below.

Process

  1. Source cells: currently harmless ‘punch biopsies’ (cylindrical cores of skin tissue removed with a small circular blade) are taken from living donor animals such as livestock or exotic animals.
  2. Isolate cells, and potentially make beneficial genetic modifications.
  3. Grow the millions of extracted cells into many billions in a bioreactor or other growth apparatus.
  4. Centrifuge (spin quickly) the products to remove the growth medium and clump the cells together.
  5. Bioassembly: put the cell clumps together into layers and allow them to fuse. A number of techniques could potentially be used, including ‘3D bioprinting’.
  6. Mature the fused cells in a bioreactor for several weeks to stimulate collagen production.
  7. Stop food supply to the cells, causing the ‘skin’ tissue to turn to hide.
  8. As the hides do not have hair or tough outer skin, a simpler than usual tanning process is used that decreases the amount of chemicals needed.

Chitosan Bioplastic (Shrilk)

A fully degradable bioplastic laminate of shrimp shell chitosan and silk fibroin protein, heralded as an exceptionally strong, biocompatible, cheap, environmentally safe alternative to plastic.

A fully degradable bioplastic can be created by isolating chitosan from shrimp shells and forming a laminate with silk fibroin protein in a structure that mimics the microarchitecture of natural insect cuticle. It is an alternative to plastic, similar in strength and toughness to an aluminium alloy but half the weight, and can be made into complex shapes with varying stiffness.

Uses

  • As a new material no widespread uses are yet known

Potential Uses

  • Alternative to plastic in bags, packaging, and disposable nappies
  • Suture for wounds that bear high loads, such as in hernia repair
  • Scaffold for tissue regeneration

Processes

  • Wide variations in stiffness, from elastic to rigid, can be achieved by controlling water content in the fabrication process.

More Information

Yeast Protein ‘Silk’ Fibres

Bioengineered yeast is fermented to create proteins like those found in spider or silkworm ‘silks’, which can be spun into ‘soft yet durable’, biodegradable fibres

Uses

  • So far a developer of the technology, Bolt Threads has produced fibres which have been used to create a hat.

Potential Uses

  • Anything that uses fibres… including woven fabrics and non-woven (composites etc)?
  • Please comment below with any research, exploratory/student projects or ideas…

Processes

  • Need more information

More Information

DNA Data Storage

DNA is nature's permanent data storage, with woolly mammoth DNA being readable after 60,000 years. It is extremely dense (able to encode the entire internet in a shoebox!) and uses little power to maintain

Nature can manufacture for us: A long term, efficient data storage medium.

Scientists have been demonstrating the storage of digital data in DNA since 2012, with current methods capable of storing 215 petabytes (215 million gigabytes) per gram of DNA (85% of the theoretical limit). However, these approaches aren’t yet ready for mainstream use; it costs $7000 to synthesise 2 megabytes of data, and another $2000 to read it. It is also currently a slow process, both in ‘writing’ through DNA synthesis, and in ‘reading’ which requires the DNA to be sequenced.

Uses

No commercial uses are known of so far, but:

Potential Uses

  • High quantity, long-term, low access rate applications (most likely), such as archival storage of large amounts of scientific data.
  • To make the DNA storage even more reliable could we harness or learn from the way Tardigrades protect/repair their DNA? Theirs stays intact even when they are frozen or dried out, for example, and they can withstand 1,000 times more radiation than other animals.

Processes

More Information

  • https://en.wikipedia.org/wiki/DNA_digital_data_storage
  • https://www.technologyreview.com/s/607880/microsoft-has-a-plan-to-add-dna-data-storage-to-its-cloud/
  • http://www.sciencemag.org/news/2017/03/dna-could-store-all-worlds-data-one-room